Managing Exacerbations in Thunderstorm Asthma: Current Insights

Josh Chatelier; Samantha Chan; Ju Ann Tan; Alastair G Stewart; Jo Anne Douglass

doi:10.2147/JIR.S324282

Managing Exacerbations in Thunderstorm Asthma: Current Insights

J Inflamm Res. 2021 Sep 8:14:4537-4550. doi: 10.2147/JIR.S324282. eCollection 2021.

Authors

Josh Chatelier^{1

2}, Samantha Chan^{1

2

3}, Ju Ann Tan^{1

2}, Alastair G Stewart^{4

5}, Jo Anne Douglass^{1

2}

Affiliations

¹ Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Parkville, Victoria, Australia.
² Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
³ Immunology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁴ Department of Biochemistry and Pharmacology, School of Biomedical Sciences, University of Melbourne, Melbourne, Victoria, Australia.
⁵ ARC Centre for Personalised Therapeutics Technologies, University of Melbourne, Melbourne, Victoria, Australia.

Abstract

Epidemic thunderstorm asthma (ETSA) occurs following a thunderstorm due to the interaction of environmental and immunologic factors. Whilst first reported in the 1980s, the world's largest event in Melbourne, Australia, on November 21, 2016 has led to a wealth of clinical literature seeking to identify its mechanisms, susceptibility risk factors, and management approaches. Thunderstorm asthma (TA) typically presents during an aeroallergen season in individuals sensitized to perennial rye grass pollen (RGP) in Australia, or fungus in the United Kingdom, in combination with meteorological factors such as thunderstorms and lightning activity. It is now well recognized that large pollen grains, which usually lodge in the upper airway causing seasonal allergic rhinitis (SAR), are ruptured during these events, leading to sub-pollen particles respirable to the lower respiratory tract causing acute asthma. The identified risk factors of aeroallergen sensitization, specifically to RGP in Australians with a history of SAR, and individuals born in Australia of South-East Asian descent as a risk factor for TA has been key in selecting appropriate patients for preventative management. Moreover, severity-determining risk factors for ETSA-related asthma admission or mortality, including pre-existing asthma or prior hospitalization, poor inhaled corticosteroid adherence, and outdoor location at the time of the storm are important in identifying those who may require more aggressive treatment approaches. Basic treatments include optimizing asthma control and adherence to inhaled corticosteroid therapy, treatment of SAR, and education regarding TA to increase recognition of at-risk days. Precision treatment approaches may be more beneficial in select individuals, including the use of allergen immunotherapy and even biologic treatment to mitigate asthma severity. Finally, we discuss the importance of environmental health literacy in the context of concerns surrounding the increased frequency of ETSA due to climate change and its implications for the frequency and severity of future events.

Keywords: epidemic thunderstorm asthma; seasonal allergic rhinitis; thunderstorm asthma.

Publication types

Review