Prostate adenocarcinoma with mucinous features - is it PSMA avid?

Patrick J Horsley; Gemma Sheehan-Dare; Katerina Mastrocostas; Caroline Fung; Andrew Kneebone; Thomas N Eade; Louise Emmet; Andre Lalak; George Hruby

doi:10.1111/1754-9485.13327

Prostate adenocarcinoma with mucinous features - is it PSMA avid?

J Med Imaging Radiat Oncol. 2022 Aug;66(5):637-640. doi: 10.1111/1754-9485.13327. Epub 2021 Sep 15.

Authors

Patrick J Horsley¹, Gemma Sheehan-Dare², Katerina Mastrocostas³, Caroline Fung⁴, Andrew Kneebone^{1

5

6}, Thomas N Eade^{1

5

6}, Louise Emmet^{2

7}, Andre Lalak⁸, George Hruby^{1

5

6}

Affiliations

¹ Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
² Department of Nuclear Medicine and Theranostics, St. Vincent's Hospital, Sydney, New South Wales, Australia.
³ Department of Radiology, Concord Hospital, Concord, New South Wales, Australia.
⁴ Department of Anatomical Pathology, Concord Hospital, Concord, New South Wales, Australia.
⁵ GenesisCare, Sydney, New South Wales, Australia.
⁶ University of Sydney, Sydney, New South Wales, Australia.
⁷ University of New South Wales, Sydney, New South Wales, Australia.
⁸ Department of Urology, Concord Hospital, Concord, New South Wales, Australia.

PMID: 34524723
DOI: 10.1111/1754-9485.13327

Abstract

Mucinous prostate adenocarcinoma represents <0.1% of prostate cancers. To our knowledge, no previous report has described the ⁶⁸ Ga-PSMA-PET characteristics of this entity at the primary site. We present a case of a fit 85-year-old with PSA 0.55 ng/mL and ISUP grade 4 acinar adenocarcinoma with mucinous features on biopsy. ⁶⁸ Ga-PSMA-PET revealed an intensely avid primary lesion in the right prostate (SUVmax 10.9), concordant with biopsy findings and encompassing both the PI-RADS 5 lesion identified on MRI and a PI-RADS 1 lesion that presumably represented the mucinous component. The patient was treated with definitive radiotherapy to the prostate and lymph nodes with 6 months of androgen deprivation therapy.

Keywords: PSMA-PET; adenocarcinoma; mucinous; prostate.

Publication types

Case Reports
Letter

MeSH terms

Adenocarcinoma* / diagnostic imaging
Adenocarcinoma* / radiotherapy
Aged, 80 and over
Androgen Antagonists
Edetic Acid
Gallium Radioisotopes
Humans
Magnetic Resonance Imaging
Male
Oligopeptides
Positron Emission Tomography Computed Tomography
Prostate / pathology
Prostate-Specific Antigen
Prostatic Neoplasms* / diagnostic imaging
Prostatic Neoplasms* / pathology
Prostatic Neoplasms* / radiotherapy

Substances

Androgen Antagonists
Gallium Radioisotopes
Oligopeptides
Edetic Acid
Prostate-Specific Antigen