Continuous-time stochastic processes for the spread of COVID-19 disease simulated via a Monte Carlo approach and comparison with deterministic models

J Math Biol. 2021 Sep 14;83(4):34. doi: 10.1007/s00285-021-01657-4.

Abstract

Two stochastic models are proposed to describe the evolution of the COVID-19 pandemic. In the first model the population is partitioned into four compartments: susceptible S, infected I, removed R and dead people D. In order to have a cross validation, a deterministic version of such a model is also devised which is represented by a system of ordinary differential equations with delays. In the second stochastic model two further compartments are added: the class A of asymptomatic individuals and the class L of isolated infected people. Effects such as social distancing measures are easily included and the consequences are analyzed. Numerical solutions are obtained with Monte Carlo simulations. Quantitative predictions are provided which can be useful for the evaluation of political measures, e.g. the obtained results suggest that strategies based on herd immunity are too risky. Finally, the models are calibrated on data referring to the second wave of infection in Italy.

Keywords: COVID-19; Epidemic model; Monte Carlo simulation; Stochastic process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Humans
  • Models, Biological
  • Monte Carlo Method
  • Pandemics
  • SARS-CoV-2
  • Stochastic Processes