Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin

Yong-Chun Lin; Xi Cao; Yun-Chao Mo; Cai-Peng Xie; Yong-Fang Zhang; Na Li; Hua-Ling Chen

doi:10.1016/j.idcr.2021.e01276

Successful treatment of hypervirulent Klebsiella pneumoniae bacteremia with combination carbapenem and rifampicin

IDCases. 2021 Sep 2:26:e01276. doi: 10.1016/j.idcr.2021.e01276. eCollection 2021.

Authors

Yong-Chun Lin¹, Xi Cao¹, Yun-Chao Mo¹, Cai-Peng Xie¹, Yong-Fang Zhang¹, Na Li¹, Hua-Ling Chen¹

Affiliation

¹ Department of Pharmacy, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.

Abstract

Hypervirulent Klebsiella pneumoniae (hvKP) with a high mucus phenotype, can cause liver abscess and extrahepatic invasive infection. The morbidity of hvKP infections has increased recently. Here we describe a case report of septicemia caused by hvKP due to the term septic arthritis of right knee joint in a 29-year-old male. The patient was persistent fever with a peak temperature at 40.6 °C. However, based on the drug sensitivity, the treatment failed frequently. The patient did not improve clinically on susceptible monotherapy antimicrobial. Combination therapy with meropenem and rifampicin (RFP) lead to clinical improvement and discharge.

Keywords: BSIs, bloodstream infections; Bacteremia; CK, creatine kinase; CK-MB, MB isoenzyme of creatine kinase; Carbapenems; GLU, glucose in the blood; Hs-CRP, hypersensitive C-reactive protein; Hypervirulent Klebsiella pneumoniae; KPLA, Klebsiella pneumoniae liver abscess; Liver abscess; RFP, Rifampicin; Rifampicin; hvKP, hypervirulent Klebsiella pneumoniae; magA, mucus related gene A; rmpA, regulator of mucoid phenotype A.

Publication types

Case Reports