Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation

Biochem Biophys Res Commun. 2021 Nov 12:578:1-6. doi: 10.1016/j.bbrc.2021.08.081. Epub 2021 Aug 29.

Abstract

Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg mice showed increased expression of genes involved in adipogenesis and lipid metabolism in the white adipose tissue. DRG2 was also identified to control adipogenesis by cooperating with peroxisome proliferator activated receptor-γ (PPAR-γ) in cultured adipocytes. Overall, the findings of the current study suggest that DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet.

Keywords: Adipogenesis; Developmentally regulated GTP-Binding protein 2 (DRG2); Lipid metabolism; Obesity; Peroxisome proliferator activated receptor-γ (PPAR-γ).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipogenesis
  • Adipose Tissue, White / cytology*
  • Adipose Tissue, White / metabolism
  • Animals
  • Body Weight
  • Cell Differentiation
  • Disease Models, Animal
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism*
  • Lipid Metabolism
  • Mice
  • Mice, Transgenic
  • PPAR gamma / metabolism*

Substances

  • DRG2 protein, human
  • PPAR gamma
  • Pparg protein, mouse
  • GTP-Binding Proteins