Membrane trafficking: Retrofusion as an escape route out of the endosome

Emily R Eden; Clare E Futter

doi:10.1016/j.cub.2021.07.055

Membrane trafficking: Retrofusion as an escape route out of the endosome

Curr Biol. 2021 Sep 13;31(17):R1037-R1040. doi: 10.1016/j.cub.2021.07.055.

Authors

Emily R Eden¹, Clare E Futter²

Affiliations

¹ UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: e.eden@ucl.ac.uk.
² UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: c.futter@ucl.ac.uk.

PMID: 34520711
DOI: 10.1016/j.cub.2021.07.055

Abstract

Intraluminal vesicles accumulate within the endosomal lumen before lysosomal delivery or extracellular release. A new study reports the development of an elegant assay showing that these vesicles can escape from the endosomal lumen by 'back-fusion' or 'retrofusion' with the endosomal limiting membrane.

Publication types

Comment

MeSH terms

Endosomes*
Intracellular Membranes*
Lysosomes

Grants and funding

MR/V013882/1/MRC_/Medical Research Council/United Kingdom