In their never-ending quest towards persistence within their host, hepatitis viruses have developed numerous ways to counteract the liver innate immunity. This review highlights the different and common mechanisms employed by these viruses to (i) establish in the liver (passive entry or active evasion from immune recognition) and (ii) actively inhibit the innate immune response (ie modulation of pattern recognition receptor expression and/or signalling pathways, modulation of interferon response and modulation of immune cells count or phenotype).
Keywords: MHC; NF-κB; PRR; anti-inflammatory; hepatic viruses; innate immunity; interferon; liver; pro-inflammatory.
© 2021 The Authors. Liver International published by John Wiley & Sons Ltd.