Obesity and Postmenopausal Hormone Receptor-positive Breast Cancer: Epidemiology and Mechanisms

Qianying Zuo; Shoham Band; Mrinali Kesavadas; Zeynep Madak Erdogan

doi:10.1210/endocr/bqab195

Obesity and Postmenopausal Hormone Receptor-positive Breast Cancer: Epidemiology and Mechanisms

Endocrinology. 2021 Dec 1;162(12):bqab195. doi: 10.1210/endocr/bqab195.

Authors

Qianying Zuo¹, Shoham Band¹, Mrinali Kesavadas¹, Zeynep Madak Erdogan^{1

2

3

4

5}

Affiliations

¹ Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
² Cancer Center at Illinois, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
³ Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
⁴ Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
⁵ Department of Biomedical and Translational Sciences, Carle Illinois, College of Medicine, University of Illinois, Urbana-Champaign, Urbana, IL, USA.

PMID: 34519778
DOI: 10.1210/endocr/bqab195

Abstract

Obesity is a potential risk for several cancers, including postmenopausal, hormone dependent breast cancers. In this review, we summarize recent studies on the impact of obesity on postmenopausal women's health and discuss several mechanisms that were proposed to increase the risk of breast carcinogenesis.

Keywords: breast cancer; estrogen receptor; growth factor signaling; inflammation; obesity.

Publication types

Review

MeSH terms

Breast Neoplasms / epidemiology*
Breast Neoplasms / etiology*
Female
Humans
Middle Aged
Obesity* / complications
Obesity* / epidemiology
Postmenopause / physiology*
Receptors, Estrogen / genetics
Receptors, Estrogen / metabolism
Risk Factors

Substances

Receptors, Estrogen