Azaphilones and Meroterpenoids from the Soft Coral-Derived Fungus Penicillium glabrum glmu003

Chem Biodivers. 2021 Nov;18(11):e2100663. doi: 10.1002/cbdv.202100663. Epub 2021 Sep 29.

Abstract

Two new azaphilone compounds, daldinins G (1) and H (2), together with nine known compounds daldinin D (3), sargassopenilline B (4), austalide V (5), austalide K (6), austalide P (7), austalide P acid (8), austalide H (9), 13-O-deacetyaustalide I (10), and 17-O-demethylaustalide B (11), were isolated from the soft coral-derived fungus Penicillium glabrum glmu003. The new structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR, mass spectra, and electronic circular dichroism (ECD) data analysis. Compound 5 showed weak inhibitory activity against pancreatic lipase (PL) with IC50 value of 23.9 μg/mL.

Keywords: PL inhibitory; Penicillium glabrum; azaphilone; meroterpenoid.

MeSH terms

  • Animals
  • Benzopyrans / chemistry
  • Benzopyrans / isolation & purification
  • Benzopyrans / pharmacology*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Lipase / antagonists & inhibitors*
  • Lipase / metabolism
  • Molecular Conformation
  • Penicillium / chemistry*
  • Pigments, Biological / chemistry
  • Pigments, Biological / isolation & purification
  • Pigments, Biological / pharmacology*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Swine
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Benzopyrans
  • Enzyme Inhibitors
  • Pigments, Biological
  • Terpenes
  • azaphilone
  • Lipase

Supplementary concepts

  • Penicillium glabrum