A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?

Yeojin Lee; Lei Ding

doi:10.1083/jcb.202108031

A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?

J Cell Biol. 2021 Oct 4;220(10):e202108031. doi: 10.1083/jcb.202108031. Epub 2021 Sep 13.

Authors

Yeojin Lee¹, Lei Ding¹

Affiliation

¹ Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY.

Abstract

Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Bone Marrow Cells
Hematopoietic Stem Cells*
Stem Cell Niche*
Synapses

Abstract

Publication types

MeSH terms

Grants and funding