High-component Reactions (HCRs): An Overview of MCRs Containing Seven or More Components as Versatile Tools in Organic Synthesis

Abstract

Recently, multi-component reactions (MCRs) have gained special attention due to their versatility for the synthesis of polycyclic heterocycles. Moreover, their applicability can become more widespread as they can be combined together as a union of MCRs. In this overview, the authors have tried to collect the MCRs containing more than seven components that can lead to effectual heterocycles in organic and/or pharmaceutical chemistry. The review contains papers published up to the end of 2020. The subject is classified based on the number of substrates, such as seven-, eight-, nine-, ten-, and more components. The authors expect their report to be helpful for researchers to clarify their route to significant MCRs.

Keywords: Multi-component reactions (MCRs); domino; eight-component; heterocycles.; high-component reactions (HCRs); macromolecules; onepot; pseudo MCRs; seven-component.