Understanding of heart failure (HF) has evolved from a simple hemodynamic problem through a neurohormonally and proinflammatory-driven syndrome to a complex multiorgan dysfunction accompanied by inadequate energy handling. This article discusses the most important clinical aspects of advanced HF pathophysiology. It presents the concept of neurohormonal activation and its deleterious effect on cardiovascular system and reflex control. The current theories regarding the role of inflammation, cytokine activation, and myocardial remodeling in HF progression are presented. Advanced HF is a multiorgan syndrome with interplay between cardiovascular system and other organs. The role of iron deficiency is also discussed.
Keywords: Cardiorespiratory reflex disbalance; Congestion; Iron deficiency; Multiorgan dysfunction; Neurohormonal activation; Sympathetic drive.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.