Therapeutic Targeting of Autophagy in Pancreatic Cancer

Mona Foth; Ignacio Garrido-Laguna; Conan G Kinsey

doi:10.1016/j.soc.2021.06.001

Therapeutic Targeting of Autophagy in Pancreatic Cancer

Surg Oncol Clin N Am. 2021 Oct;30(4):709-718. doi: 10.1016/j.soc.2021.06.001. Epub 2021 Jul 22.

Authors

Mona Foth¹, Ignacio Garrido-Laguna², Conan G Kinsey³

Affiliations

¹ Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.
² Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA; Department of Internal Medicine, Division of Oncology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
³ Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA; Department of Internal Medicine, Division of Oncology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address: Conan.Kinsey@hci.utah.edu.

PMID: 34511191
DOI: 10.1016/j.soc.2021.06.001

Abstract

This article provides a brief review of the therapeutic opportunity of inhibiting autophagy in pancreatic cancer. The autophagic process, importance of autophagy in pancreatic cancer, relevant clinical trials, and new agents in preclinical and clinical development are discussed.

Keywords: Autophagy; Autophagy clinical trials; Pancreatic cancer; Pancreatic cancer clinical trials; Therapeutics.

Published by Elsevier Inc.

Publication types

Review

MeSH terms

Autophagy
Humans
Pancreatic Neoplasms* / drug therapy