2D materials for bone therapy

Xiangjiang Wang; Xianjing Han; Chaozhou Li; Zhi Chen; Hao Huang; Jindong Chen; Chenshuo Wu; Taojian Fan; Tianzhong Li; Weichun Huang; Omar A Al-Hartomy; Ahmed Al-Ghamdi; Swelm Wageh; Fei Zheng; Abdullah G Al-Sehemi; Guiqing Wang; Zhongjian Xie; Han Zhang

doi:10.1016/j.addr.2021.113970

2D materials for bone therapy

Adv Drug Deliv Rev. 2021 Nov:178:113970. doi: 10.1016/j.addr.2021.113970. Epub 2021 Sep 10.

Authors

Xiangjiang Wang¹, Xianjing Han¹, Chaozhou Li², Zhi Chen², Hao Huang², Jindong Chen¹, Chenshuo Wu², Taojian Fan³, Tianzhong Li⁴, Weichun Huang⁵, Omar A Al-Hartomy⁶, Ahmed Al-Ghamdi⁶, Swelm Wageh⁶, Fei Zheng², Abdullah G Al-Sehemi⁷, Guiqing Wang¹, Zhongjian Xie⁸, Han Zhang⁹

Affiliations

¹ The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan 511518, Guangdong, China.
² Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
³ College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China.
⁴ Shenzhen International Institute for Biomedical Research, Shenzhen 518116, Guangdong, China.
⁵ Nantong Key Lab of Intelligent and New Energy Materials, School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, PR China.
⁶ Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
⁷ Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61413, P.O. Box 9004, Saudi Arabia.
⁸ Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, PR China; Shenzhen International Institute for Biomedical Research, Shenzhen 518116, Guangdong, China.
⁹ Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address: hzhang@szu.edu.cn.

PMID: 34509576
DOI: 10.1016/j.addr.2021.113970

Abstract

Due to their prominent physicochemical properties, 2D materials are broadly applied in biomedicine. Currently, 2D materials have achieved great success in treating many diseases such as cancer and tissue engineering as well as bone therapy. Based on their different characteristics, 2D materials could function in various ways in different bone diseases. Herein, the application of 2D materials in bone tissue engineering, joint lubrication, infection of orthopedic implants, bone tumors, and osteoarthritis are firstly reviewed comprehensively together. Meanwhile, different mechanisms by which 2D materials function in each disease reviewed below are also reviewed in detail, which in turn reveals the versatile functions and application of 2D materials. At last, the outlook on how to further broaden applications of 2D materials in bone therapies based on their excellent properties is also discussed.

Keywords: 2D materials; Antibacterial; Bone tissue engineering; Bone tumors; Joint lubrication; Osteoarthritis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocompatible Materials / chemistry
Biocompatible Materials / pharmacology*
Bone Diseases / drug therapy*
Bone and Bones / drug effects*
Humans
Prostheses and Implants*
Tissue Engineering

Substances

Biocompatible Materials