Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides

Chengdong Wang; Yingjie Guo; Xiaoming Wang; Zheng Wang; Kuiling Ding

doi:10.1002/chem.202102847

Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides

Chemistry. 2021 Nov 17;27(64):15903-15907. doi: 10.1002/chem.202102847. Epub 2021 Oct 1.

Authors

Chengdong Wang¹, Yingjie Guo², Xiaoming Wang², Zheng Wang², Kuiling Ding^{1

2}

Affiliations

¹ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
² State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

PMID: 34506052
DOI: 10.1002/chem.202102847

Abstract

An efficient nickel-catalyzed regioselective hydroarylation of 1,3-dienes with aryl halides and a silane has been developed, affording a range of allylic arenes in good to excellent yields under mild conditions. This method exhibits broad substrate scope, and excellent functional group tolerance. Late-stage modification of complex architectures was demonstrated.

Keywords: 1,3-dienes; aryl halide; coupling reactions; hydroarylation; nickel.

Abstract

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