PRMT5 Prevents Dilated Cardiomyopathy via Suppression of Protein O-GlcNAcylation

Circ Res. 2021 Oct 15;129(9):857-871. doi: 10.1161/CIRCRESAHA.121.319456. Epub 2021 Sep 10.

¹ State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, China (Z.L., J.X., C.X., L.L., N.H., Y.T., X.C., T.W., Z.Y., J.W., X.Y.).
² Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, China (Y.S., Y.Z.).
³ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), China (J.S.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: cardiomyopathies; genetic therapy; heart failure; homeostasis; protein-arginine N-methyltransferases.