LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28

Circ Res. 2021 Oct 15;129(9):843-856. doi: 10.1161/CIRCRESAHA.121.319590. Epub 2021 Sep 10.

Authors

Xiaodong Liang¹, Shuo Wu¹, Zilong Geng¹, Li Liu¹, Shasha Zhang¹, Shiyan Wang², Yan Zhang³, Yu Huang^{4

5}, Bing Zhang¹

Affiliations

¹ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, China (X.L., S. Wu, Z.G., L.L., S.Z., B.Z.).
² School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, China (S. Wang).
³ Renji-Med Clinical Stem Cell Research Center, Renji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, China (Y.Z.).
⁴ School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China (Y.H.).
⁵ Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China (Y.H.).

PMID: 34503347
DOI: 10.1161/CIRCRESAHA.121.319590

Abstract

[Figure: see text].

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Endocardium / metabolism
Endocardium / pathology
Epigenesis, Genetic
Epithelial-Mesenchymal Transition*
Heart Valve Diseases / genetics
Heart Valve Diseases / metabolism*
Heart Valve Diseases / pathology
Heart Valves / metabolism
Heart Valves / pathology
Histone Code
Human Umbilical Vein Endothelial Cells / metabolism
Humans
Mice
Mice, Inbred C57BL
Promoter Regions, Genetic
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism*
Snail Family Transcription Factors / genetics
Snail Family Transcription Factors / metabolism
Tripartite Motif-Containing Protein 28 / genetics
Tripartite Motif-Containing Protein 28 / metabolism*

Substances

Larp7 protein, mouse
RNA-Binding Proteins
Snai2 protein, mouse
Snail Family Transcription Factors
Trim28 protein, mouse
Tripartite Motif-Containing Protein 28