Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities

Nat Prod Res. 2022 Jun;36(12):3229-3233. doi: 10.1080/14786419.2021.1956923. Epub 2021 Sep 9.

Abstract

Sixteen compounds (1-16) were isolated from Impatiens chapaensis. Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the first to identify compounds 1, 5-7, 10, 12-14, and 16 from the genus Impatiens. Seven chosen isolates (5, 7, 10, 11, 12, 15, and 16) were submitted for α-glucosidase inhibition assays with acarbose as the positive control (IC50 = 227.14 ± 13.71 µM). Flavonoid 5 exhibited a significant inhibitory effect (IC50 = 101.00 ± 9.01 µM).

Keywords: Balsaminaceae; Impatiens chapaensis; flavonoid glycoside; neolignan glycoside; sesquiterpene.

MeSH terms

  • Flavonoids / chemistry
  • Flavonoids / pharmacology
  • Glycoside Hydrolase Inhibitors* / chemistry
  • Glycoside Hydrolase Inhibitors* / pharmacology
  • Impatiens* / chemistry
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology
  • Plant Extracts* / chemistry
  • Plant Extracts* / pharmacology
  • alpha-Glucosidases

Substances

  • Flavonoids
  • Glycoside Hydrolase Inhibitors
  • Phytochemicals
  • Plant Extracts
  • alpha-Glucosidases