A photosensitizer with conformational restriction for enhanced photodynamic therapy

Haiqiao Huang; Saran Long; Daipeng Huang; Jianjun Du; Jiangli Fan; Xiaojun Peng

doi:10.1039/d1cc03591f

A photosensitizer with conformational restriction for enhanced photodynamic therapy

Chem Commun (Camb). 2021 Sep 9;57(72):9100-9103. doi: 10.1039/d1cc03591f.

Authors

Haiqiao Huang¹, Saran Long^{1

2

3}, Daipeng Huang¹, Jianjun Du^{1

2

3}, Jiangli Fan^{1

2

3}, Xiaojun Peng^{1

2

3}

Affiliations

¹ State Key Laboratory of Fine Chemicals, Dalian university of Technology, 2 Linggong Road, Dalian 116024, P. R. China. pengxj@dlut.edu.cn.
² Shenzhen Research Institute, Dalian University of Technology, Nanshan District, Shenzhen, 518057, P. R. China.
³ Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo 315016, P. R. China.

PMID: 34498645
DOI: 10.1039/d1cc03591f

Abstract

A rigid hemicyanine CSZ-J and a flexible molecule ESZ-J were synthesized. In particular, the conformationally restrained CSZ-J had higher fluorescence quantum yields, longer fluorescence lifetimes and higher triplet state quantum yields. CSZ-J could generate highly cytotoxic ROS simultaneously via type I and type II processes. This will contribute to the design and development of new photosensitizers in the future.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Carbocyanines / chemistry
Carbocyanines / pharmacology*
Cell Proliferation / drug effects
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
MCF-7 Cells
Molecular Conformation
Photochemotherapy*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Reactive Oxygen Species / metabolism

Substances

Antineoplastic Agents
Carbocyanines
Photosensitizing Agents
Reactive Oxygen Species
tetramethylene hemicyanine