Prebiotic, Antioxidant, and Immunomodulatory Properties of Acidic Exopolysaccharide From Marine Rhodotorula RY1801

Zheng Wang; Yanchen Zhao; Yan Jiang; Weihua Chu

doi:10.3389/fnut.2021.710668

Prebiotic, Antioxidant, and Immunomodulatory Properties of Acidic Exopolysaccharide From Marine Rhodotorula RY1801

Front Nutr. 2021 Aug 23:8:710668. doi: 10.3389/fnut.2021.710668. eCollection 2021.

Authors

Zheng Wang¹, Yanchen Zhao¹, Yan Jiang², Weihua Chu¹

Affiliations

¹ State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
² Animal, Plant and Food Inspection Center of Nanjing Customs, Nanjing, China.

Abstract

In this study, an extracellular acidic polysaccharide (EAPS) from marine Rhodotorula sp. RY1801 was extracted, and its biological properties were investigated. EAPS is mainly composed of monosaccharides, including mannose, rhamnose, glucose, galactose, and fucose, had an average molecular weight of 5.902 × 10⁷ Da. The results indicated that EAPS can promote the growth of Lactobacillus acidophilus and L. acidophilus plantarum. EAPS is capable of scavenging both superoxide anion and hydroxyl radicals in vitro. The highest scavenging rate of superoxide anion and hydroxyl radicals is 29 and 84%, respectively. Using in vivo model, we found that the EAPS can expand the lifespan and increase the disease resistance of Caenorhabditis elegans against Klebsiella pneumoniae infection via the DAF-2/DAF-16 pathway. These results suggested that EAPS from marine Rhodotorula sp. RY1801 could promote the growth of beneficial bacteria and can be used as an antioxidant and immunomodulator, which had considerable potential in the food and health industry.

Keywords: Rhodotorula; acidic exopolysaccharide; antioxidant; immunomodulatory; prebiotic.