Prevalence of Chronic Kidney Diseases in Patients with Diabetes Mellitus in the Middle East: A Systematic Review and Meta-Analysis

Abdallah Y Naser; Hassan Alwafi; Basil Alotaibi; Emad Salawati; Mohammed Samannodi; Zahra Alsairafi; Abeer F R Alanazi; Mohammad S Dairi

doi:10.1155/2021/4572743

Prevalence of Chronic Kidney Diseases in Patients with Diabetes Mellitus in the Middle East: A Systematic Review and Meta-Analysis

Int J Endocrinol. 2021 Aug 28:2021:4572743. doi: 10.1155/2021/4572743. eCollection 2021.

Authors

Abdallah Y Naser¹, Hassan Alwafi², Basil Alotaibi³, Emad Salawati⁴, Mohammed Samannodi², Zahra Alsairafi⁵, Abeer F R Alanazi⁶, Mohammad S Dairi²

Affiliations

¹ Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Al-Isra University, Amman, Jordan.
² Faculty of Medicine, Umm Al Qura University, Mecca, Saudi Arabia.
³ College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
⁴ Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
⁵ Faculty of Pharmacy, Pharmacy Practice Department, Kuwait University, Kuwait City, Kuwait.
⁶ Department of Pharmaceutical and Biological Sciences, UCL School of Pharmacy, London, UK.

Abstract

Aims: The prevalence of CKD in patients with diabetes mellitus in the Middle East region is unknown. Therefore, we aimed to understand the pooled prevalence of CKD in patients with diabetes mellitus in the Middle East region.

Methods: PubMed, Embase, and Cochrane databases were searched for relevant studies up to October 2020. The search strategy was conducted using both keywords and MeSH terms. Randomised controlled trials (RCTs) and observational studies that included patients from all age groups and any study design that reported on the prevalence of CKD in patients with diabetes mellitus were included. The pooled estimate for the prevalence of CKD in patients with diabetes was calculated using random-effect models with 95% confidence intervals (CIs).

Results: A total of 489 citations were identified, of which only nine studies matched our inclusion criteria and were included in the meta-analysis. All of the studies used an observational study design covering a total of 59,395 patients with type 2 diabetes mellitus. The pooled estimate of the prevalence of CKD in patients with diabetes mellitus was 28.96% (95% CI: 19.80-38.11).

Conclusions: A high prevalence of CKD in patients with diabetes mellitus in the Middle East region was found. Further epidemiological studies are warranted in this area to have a better estimate of the prevalence of CKD among DM in the Middle East region.

Publication types

Review