Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa

World J Gastroenterol. 2021 Aug 21;27(31):5152-5170. doi: 10.3748/wjg.v27.i31.5152.

Abstract

Helicobacter pylori (H. pylori) infects approximately 50% of all humans globally. Persistent H. pylori infection causes multiple gastric and extragastric diseases, indicating the importance of early diagnosis and timely treatment. H. pylori eradication produces dramatic changes in the gastric mucosa, resulting in restored function. Consequently, to better understand the importance of H. pylori eradication and clarify the subsequent recovery of gastric mucosal functions after eradication, we summarize histological, endoscopic, and gastric microbiota changes to assess the therapeutic effects on the gastric mucosa.

Keywords: Endoscopic findings; Eradication therapy; Gastric mucosa; Gastrointestinal microbiota; Helicobacter pylori; Histology.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Gastric Mucosa
  • Helicobacter Infections* / drug therapy
  • Helicobacter pylori*
  • Humans
  • Microbiota*
  • Stomach

Substances

  • Anti-Bacterial Agents