The leading role of adsorbed lead in PM2.5-induced hippocampal neuronal apoptosis and synaptic damage

Fang Liu; Zengjin Wang; Yongyi Wei; Rongrong Liu; Cuijuan Jiang; Chen Gong; Yin Liu; Bing Yan

doi:10.1016/j.jhazmat.2021.125867

The leading role of adsorbed lead in PM_2.5-induced hippocampal neuronal apoptosis and synaptic damage

J Hazard Mater. 2021 Aug 15:416:125867. doi: 10.1016/j.jhazmat.2021.125867. Epub 2021 Apr 20.

Authors

Fang Liu¹, Zengjin Wang¹, Yongyi Wei¹, Rongrong Liu², Cuijuan Jiang³, Chen Gong³, Yin Liu⁴, Bing Yan⁵

Affiliations

¹ School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
² Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China.
³ School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China.
⁴ School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 330106, China. Electronic address: liuyin19860406@163.com.
⁵ Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China; School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China. Electronic address: drbingyan@yahoo.com.

PMID: 34492814
DOI: 10.1016/j.jhazmat.2021.125867

Abstract

Neurodegenerative diseases may be caused by air pollution, such as PM_2.5. However, particles still need to be elucidated the mechanism of synergistic neurotoxicity induced by pollutant-loading PM_2.5. In this study, we used a reductionist approach to study leading role of lead (Pb) in PM_2.5-induced hippocampal neuronal apoptosis and synaptic damage both in vivo and in vitro. Pb in PM_2.5 caused neurotoxicity: 1) by increasing ROS levels and thus causing apoptosis in neuronal cells and 2) by decreasing the expression of PSD95 via interfering with the calcium signaling pathway through cAMP/CREB/pCREB/BDNF/PSD95 pathway and reducing the synapse length by 50%. This study clarifies a key factor in PM_2.5-induced neurotoxicity and provides the experimental basis for reducing PM_2.5-induced neurotoxicity.

Keywords: Ca(2+) signaling pathway; Hippocampus; Lead; PM(2.5); ROS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Hippocampus*
Lead* / toxicity
Particulate Matter / toxicity
Synapses

Substances

Particulate Matter
Lead