The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population

Abstract

Background: Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and oxidative stress hallmarks.

Objective: The research aims to know any disturbances in haematological parameters and antioxidant system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.

Methods: A case-control research meeting following the McDonald criterion was conducted on 100 RRMS patients and 100 controls.

Results: Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate (ESR), and total leucocyte counts (TLCs) were increased significantly, but copper (Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide metabolites (NOx) and lymphocyte were not changed significantly if compared with that of controls.

Conclusion: Findings from our study revealed that some defects were detected in haematological profiles in the Kurdish population and disturbance of immunological parameters. In addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients may be beneficial.

Keywords: And relapsing-remitting multiple sclerosis; Erythrocyte sedimentation rate; Hematological parameters; Inflammation; Oxidative stress.