Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine

Circulation. 2021 Sep 7;144(10):759-762. doi: 10.1161/CIRCULATIONAHA.121.056324. Epub 2021 Sep 7.

Matthew J Daniels^{1

2

3}, Luca Fusi⁴, Christopher Semsarian⁵, Srihari S Naidu⁶

¹ Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, United Kingdom (M.J.D.).
² Division of Cardiovascular Sciences, Manchester Academic Health Sciences Center (M.J.D.), University of Manchester, Manchester, United Kingdom.
³ Division of Cell Matrix Biology and Regenerative Medicine (M.J.D.), University of Manchester, Manchester, United Kingdom.
⁴ Randall Center for Cell and Molecular Biophysics and BHF Center for Research Excellence, King's College London, United Kingdom (L.F.).
⁵ Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Australia (C.S.).
⁶ Hypertrophic Cardiomyopathy Center, Department of Cardiology, Westchester Medical Center, Valhalla, NY (S.S.N.).

No abstract available

Keywords: MYK-461; cardiomyopathy, hypertrophic; heart failure, systolic; myosins.

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