Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

Lunzhi Yuan; Huachen Zhu; Ming Zhou; Jian Ma; Rirong Chen; Liuqin Yu; Wenjia Chen; Wenshan Hong; Jia Wang; Yao Chen; Kun Wu; Wangheng Hou; Yali Zhang; Shengxiang Ge; Yixin Chen; Quan Yuan; Qiyi Tang; Tong Cheng; Yi Guan; Ningshao Xia

doi:10.1007/s13238-021-00874-3

Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

Protein Cell. 2022 Jan;13(1):72-77. doi: 10.1007/s13238-021-00874-3. Epub 2021 Sep 7.

Authors

Lunzhi Yuan^#¹, Huachen Zhu^#^{2

3}, Ming Zhou^#¹, Jian Ma^#¹, Rirong Chen^#^{2

3}, Liuqin Yu^{2

3}, Wenjia Chen^{2

3}, Wenshan Hong^{2

3}, Jia Wang^{2

3}, Yao Chen¹, Kun Wu¹, Wangheng Hou¹, Yali Zhang¹, Shengxiang Ge¹, Yixin Chen¹, Quan Yuan¹, Qiyi Tang⁴, Tong Cheng⁵, Yi Guan^{6

7}, Ningshao Xia^{8

9}

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China.
² State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
³ Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, 515063, China.
⁴ Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA. qiyi.tang@howard.edu.
⁵ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China. tcheng@xmu.edu.cn.
⁶ State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. yguan@hku.hk.
⁷ Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, 515063, China. yguan@hku.hk.
⁸ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361000, China. nsxia@xmu.edu.cn.
⁹ Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, 361102, China. nsxia@xmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Neutralizing / biosynthesis
Antibodies, Viral / biosynthesis
Body Weight / immunology*
COVID-19 / immunology
COVID-19 / pathology*
COVID-19 / virology
Disease Models, Animal
Disease Progression
Humans
Immunohistochemistry
Lung / immunology
Lung / pathology*
Lung / virology
Male
Mesocricetus
Nasal Cavity / virology
RNA, Viral / genetics*
RNA, Viral / immunology
SARS-CoV-2 / pathogenicity*
Severity of Illness Index
Viral Load

Substances

Antibodies, Neutralizing
Antibodies, Viral
RNA, Viral

Grants and funding

U54 MD007597/MD/NIMHD NIH HHS/United States