Cryptic insertion of CBFB into MYH11 leading to a type D fusion in acute myeloid leukemia with normal karyotype

Int J Lab Hematol. 2022 Feb;44(1):e36-e39. doi: 10.1111/ijlh.13694. Epub 2021 Sep 6.

Authors

Katsuya Yamamoto¹, Keiji Kurata¹, Akihito Kitao¹, Rina Sakai¹, Sakuya Matsumoto¹, Hisayuki Matsumoto², Jun Saegusa², Kimikazu Yakushijin¹, Hironobu Minami¹

Affiliations

¹ Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
² Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.

PMID: 34490987
DOI: 10.1111/ijlh.13694

No abstract available

Keywords: CBFB; MYH11; FISH; acute leukemias; cryptic insertion.

Publication types

Case Reports
Letter

MeSH terms

Core Binding Factor beta Subunit / genetics*
Core Binding Factor beta Subunit / metabolism
Humans
Karyotype*
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism
Male
Middle Aged
Myosin Heavy Chains / genetics*
Myosin Heavy Chains / metabolism
Oncogene Proteins, Fusion / genetics*
Oncogene Proteins, Fusion / metabolism

Substances

CBFB protein, human
Core Binding Factor beta Subunit
MYH11 protein, human
Oncogene Proteins, Fusion
Myosin Heavy Chains