Omacetaxine added to a standard acute myeloid leukaemia chemotherapy regimen reduces cellular FLIP levels, markedly increasing the incidence of eccrine hidradenitis

Br J Haematol. 2021 Nov;195(3):e138-e141. doi: 10.1111/bjh.17715. Epub 2021 Sep 7.

Authors

Jonwei Hwang¹, Naina Singh², Marylee Braniecki³, Betul Gok Yavuz², Maria M Tsoukas⁴, John G Quigley²

Affiliations

¹ University of Illinois College of Medicine, Chicago, IL, USA.
² Department of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL, USA.
³ Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
⁴ Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.

PMID: 34490614
DOI: 10.1111/bjh.17715

No abstract available

Keywords: cellular FLIP; hidradenitis; leukemia; omacetaxine; rash.

Publication types

Clinical Trial, Phase I
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / adverse effects
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Apoptosis
CASP8 and FADD-Like Apoptosis Regulating Protein / analysis*
CASP8 and FADD-Like Apoptosis Regulating Protein / biosynthesis
CASP8 and FADD-Like Apoptosis Regulating Protein / genetics
Cyclophosphamide / administration & dosage
Cytarabine / administration & dosage
Daunorubicin / administration & dosage
Down-Regulation
Drug Eruptions / etiology
Hidradenitis / chemically induced*
Hidradenitis / pathology
Homoharringtonine / administration & dosage
Homoharringtonine / adverse effects
Homoharringtonine / pharmacology*
Humans
Incidence
Leukemia, Myeloid, Acute / drug therapy*
Mercaptopurine / administration & dosage
Myeloid Cell Leukemia Sequence 1 Protein / analysis
Neoplasm Proteins / analysis*
Neoplasm Proteins / biosynthesis
Neoplasm Proteins / genetics
Neutrophils
Protein Kinase Inhibitors / administration & dosage
Protein Kinase Inhibitors / adverse effects
Protein Kinase Inhibitors / pharmacology*
Sweat Glands / chemistry
Sweat Glands / drug effects
Sweat Glands / pathology

Substances

Antineoplastic Agents, Phytogenic
CASP8 and FADD-Like Apoptosis Regulating Protein
MCL1 protein, human
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins
Protein Kinase Inhibitors
Cytarabine
Homoharringtonine
Cyclophosphamide
Mercaptopurine
Daunorubicin

Supplementary concepts

7+3 protocol