The Roles of CCR9/CCL25 in Inflammation and Inflammation-Associated Diseases

Xue Wu; Meng Sun; Zhi Yang; Chenxi Lu; Qiang Wang; Haiying Wang; Chao Deng; Yonglin Liu; Yang Yang

doi:10.3389/fcell.2021.686548

The Roles of CCR9/CCL25 in Inflammation and Inflammation-Associated Diseases

Front Cell Dev Biol. 2021 Aug 19:9:686548. doi: 10.3389/fcell.2021.686548. eCollection 2021.

Authors

Xue Wu^{1

2}, Meng Sun³, Zhi Yang^{1

2}, Chenxi Lu^{1

2}, Qiang Wang¹, Haiying Wang¹, Chao Deng⁴, Yonglin Liu¹, Yang Yang^{1

2}

Affiliations

¹ Department of Paediatrics, Shenmu Hospital, School of Life Sciences and Medicine, Northwest University, Shenmu, China.
² Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.
³ Department of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
⁴ Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Abstract

Chemokine is a structure-related protein with a relatively small molecular weight, which can target cells to chemotaxis and promote inflammatory response. Inflammation plays an important role in aging. C-C chemokine receptor 9 (CCR9) and its ligand C-C chemokine ligand 25 (CCL25) are involved in the regulating the occurrence and development of various diseases, which has become a research hotspot. Early research analysis of CCR9-deficient mouse models also confirmed various physiological functions of this chemokine in inflammatory responses. Moreover, CCR9/CCL25 has been shown to play an important role in a variety of inflammation-related diseases, such as cardiovascular disease (CVD), rheumatoid arthritis, hepatitis, inflammatory bowel disease, asthma, etc. Therefore, the purpose of this review gives an overview of the recent advances in understanding the roles of CCR9/CCL25 in inflammation and inflammation-associated diseases, which will contribute to the design of future experimental studies on the potential of CCR9/CCL25 and advance the research of CCR9/CCL25 as pharmacological inflammatory targets.

Keywords: CCL25; CCR9; autoimmune; chemokine; inflammatory disease.

Publication types

Review