Frequency of deep vein thrombosis at admission for acute stroke and associated factors: a cross-sectional study

Takahisa Mori; Kazuhiro Yoshioka; Yuhei Tanno

doi:10.1186/s12959-021-00315-5

Frequency of deep vein thrombosis at admission for acute stroke and associated factors: a cross-sectional study

Thromb J. 2021 Sep 6;19(1):62. doi: 10.1186/s12959-021-00315-5.

Authors

Takahisa Mori¹, Kazuhiro Yoshioka², Yuhei Tanno^{2

3}

Affiliations

¹ Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, 247-8533, Kamakura City, Kanagawa, Japan. morit-koc@umin.net.
² Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, 247-8533, Kamakura City, Kanagawa, Japan.
³ Department of Neurology, Nakatsugawa Municipal General Hospital, Komaba 1522-1, Gifu, 508-8502, Nakatsugawa City, Japan.

Abstract

Background: Intermittent pneumatic compression (IPC) is commonly used to prevent deep vein thrombosis (DVT) during hospitalization in patients with acute stroke. However, if DVT exists at admission, IPC of the legs with DVT may cause migration of the thrombi, resulting in pulmonary emboli. Whole-leg ultrasonography (wl-US) is a practical tool to detect DVT; however, wl-US is not always performed at admission in all stroke patients. This retrospective cross-sectional study aimed to investigate DVT frequency and identify significant factors indicating the presence of DVT at admission for acute stroke.

Methods: We included patients admitted within 24 h of stroke onset between 2017 and 2019. Patients who did not undergo blood tests for D-dimer or wl-US within 72 h of arrival were excluded. We collected patient data on age; sex; anthropometric variables; presence of DVT on wl-US; and biomarkers such as D-dimer, high-sensitivity C-reactive protein (hs-CRP), and lipids.

Results: Of 1129 acute stroke patients, 917 met our inclusion criteria. DVT was detected in 161 patients (17.6 %). Patients with DVT were older; were more likely to be female; had lower body weight; had higher D-dimer and hs-CRP levels; had lower albumin, hemoglobin, and triglyceride levels; and had higher National Institutes of Health Stroke Scale and pre-stroke modified Rankin scale scores than patients without DVT (n = 756). In addition, multiple logistic regression analysis showed that sex (female) and D-dimer levels (≥ 1.52 µg/mL) were independent significant factors for the presence of DVT. Among 161 patients with DVT, 78 (48.4 %) had both these significant factors. Among 756 patients without DVT, 602 (79.6 %) had no or one significant factor. The odds ratio of the presence of DVT in patients with both significant factors was 6.29, using patients without any significant factors as the group for comparison.

Conclusions: The frequency of DVT is high in acute stroke patients at admission. Female sex and a high D-dimer level were independent significant factors for the presence of DVT. Therefore, in patients with these two significant factors at admission, IPC should be avoided or wl-US should be performed before IPC.

Keywords: D-dimer; Deep vein thrombosis; Frequency; Intermittent pneumatic compression; Stroke; Ultrasonography.