Carbohydrazide Analogues: A Review of Synthesis and Biological Activities

Abstract

Carbohydrazides and their Schiff bases are important classes of heterocycles that are not only employed in the area of organic chemistry but also have tremendous applications in physical and inorganic chemistry. A series of potentially bioactive compounds containing carbohydrazide functionality and their hydrazone derivatives have been synthesized and screened for antibacterial, anticancer, antifungal and anti-inflammatory, etc. This brief review discloses some synthetic routes to so many reported carbohydrazides, their Schiff bases, their biological activities, and their structure-activity relationship.

Keywords: Carbohydrazide; biological activities; hydrazinolysis; hydrazone; schiff bases; structure-activity relationship.