Serum tissue inhibitor of MMP-1 levels at any moment of the first week of spontaneous intracerebral hemorrhage may predict early mortality

Biomark Med. 2021 Oct;15(14):1245-1251. doi: 10.2217/bmm-2020-0859. Epub 2021 Sep 7.

Abstract

Aim: To determine whether serum levels of MMP-9 and tissue inhibitor of matrix metalloproteinases (TIMP)-1 during the first week after spontaneous intracerebral hemorrhage (SIH) could be used for mortality prediction. Materials & methods: We included 117 patients with severe supratentorial SIH (defined as Glasgow Coma Scale <9). We determined serum concentrations of MMP-9 and TIMP-1 at days 1, 4 and 8 of severe SIH diagnosis. Results: The area under curve of serum TIMP-1 concentrations at days 1, 4 and 8 to predict 30-day mortality of 75% (p < 0.001), 82% (p < 0.001) and 73% (p < 0.001). Conclusion: Thus, the novel findings of our study were that serum levels of TIMP-1 during the first week of SIH may be used for mortality prediction.

Keywords: TIMP-1; mortality; patients; spontaneous intracerebral hemorrhage.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / metabolism
  • Cerebral Hemorrhage / metabolism*
  • Cerebral Hemorrhage / mortality*
  • Female
  • Glasgow Coma Scale
  • Humans
  • Male
  • Matrix Metalloproteinase 1 / metabolism*
  • Matrix Metalloproteinase 9 / metabolism
  • Middle Aged
  • Prospective Studies
  • Tissue Inhibitor of Metalloproteinase-1 / metabolism

Substances

  • Biomarkers
  • Tissue Inhibitor of Metalloproteinase-1
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 1