Does timing of phytonutrient intake influence the suppression of postprandial oxidative stress? A systematic literature review

Margaret Murray; Sophie Selby-Pham; Beau-Luke Colton; Louise Bennett; Gary Williamson; Aimee L Dordevic

doi:10.1016/j.redox.2021.102123

Does timing of phytonutrient intake influence the suppression of postprandial oxidative stress? A systematic literature review

Redox Biol. 2021 Oct:46:102123. doi: 10.1016/j.redox.2021.102123. Epub 2021 Sep 1.

Authors

Margaret Murray¹, Sophie Selby-Pham², Beau-Luke Colton³, Louise Bennett⁴, Gary Williamson⁵, Aimee L Dordevic⁶

Affiliations

¹ School of Chemistry, Monash University, Clayton, 3800, Victoria, Australia; Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, 3168, Victoria, Australia. Electronic address: margaret.murray@monash.edu.
² School of Chemistry, Monash University, Clayton, 3800, Victoria, Australia. Electronic address: sophie.selby-pham@monash.edu.
³ Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, 3168, Victoria, Australia. Electronic address: beau.colton@gmail.com.
⁴ School of Chemistry, Monash University, Clayton, 3800, Victoria, Australia. Electronic address: louise.bennett1@monash.edu.
⁵ Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, 3168, Victoria, Australia. Electronic address: gary.williamson1@monash.edu.
⁶ Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, 3168, Victoria, Australia. Electronic address: aimee.dordevic@monash.edu.

Abstract

Background: Postprandial oxidative stress markers in blood are generated transiently from various tissues and cells following high-fat and/or high-carbohydrate (HFHC) meals, and may be suppressed by certain phytonutrients, such as polyphenols and carotenoids. However, the transient presence of phytonutrients in circulation suggests that timing of consumption, relative to the meal, could be important. This systematic review investigates the effect of timing of phytonutrient intake on blood markers of postprandial oxidative processes.

Method: EMBASE, Medline, Scopus and Web of Science were searched up to December 2020. Eligible studies met the criteria: 1) healthy human adults; 2) phytonutrient(s) consumed in solid form within 24 h of a HFHC meal; 3) postprandial measurements of oxidative stress or antioxidants in blood; and 4) controlled study design. Cohen's d effect sizes were calculated to compare studies.

Results: Nine studies, involving 256 participants, were included. Phytonutrients were consumed either at the same time, 1 h before, or the day (>12 h) before a HFHC meal. Significant decreases in blood markers - plasma lipid hydroperoxides, plasma malondialdehyde, serum sNox2-dp, serum 8-iso-PGF2α, platelet p47^phox phosphorylation, and Keap-1 and p47^phox protein levels in mononuclear cells (MNCs) - were observed where the phytonutrient was consumed together with the challenge meal (n = 4). Lack of any effect on oxidative stress markers was observed where phytonutrients were consumed with (n = 1), 1 h before (n = 1), and the day before (n = 2) the HFHC meal.

Conclusion: Phytonutrients consumed with a HFHC meal significantly suppressed some markers of oxidative stress in blood. Although there were only a limited number of studies, it appears that suppression appeared effective at the time of peak phytonutrient concentration in plasma. However, further studies are required to confirm the observations and systematically optimise the effect of timing.

Keywords: Antioxidant; Human; Oxidative stress; Phytochemical; Phytonutrient; Postprandial.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Antioxidants
Cross-Over Studies
Humans
Malondialdehyde
Oxidative Stress*
Phytochemicals
Postprandial Period*

Substances

Antioxidants
Phytochemicals
Malondialdehyde