Application and advantages of zebrafish model in the study of neurovascular unit

Eur J Pharmacol. 2021 Nov 5:910:174483. doi: 10.1016/j.ejphar.2021.174483. Epub 2021 Sep 2.

Abstract

The concept of "Neurovascular Unit" (NVU) was put forward, so that the research goal of Central Nervous System (CNS) diseases gradually transitioned from a single neuron to the structural and functional integrity of the NVU. Zebrafish has the advantages of high homology with human genes, strong reproductive capacity and visualization of neural circuits, so it has become an emerging model organism for NVU research and has been applied to a variety of CNS diseases. Based on CNKI (https://www.cnki.net/) and PubMed (https://pubmed.ncbi.nlm.nih.gov/about/) databases, the author of this article sorted out the relevant literature, analyzed the construction of a zebrafish model of various CNS diseases，and the use of diagrams showed the application of zebrafish in the NVU, revealed its relationship, which would provide new methods and references for the treatment and research of CNS diseases.

Keywords: Central nervous system diseases; Neurovascular unit; Traditional Chinese medicine intervention; Zebrafish.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood-Brain Barrier / cytology
  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / physiology
  • Central Nervous System / blood supply
  • Central Nervous System / drug effects
  • Central Nervous System / physiology*
  • Central Nervous System Agents / pharmacology*
  • Central Nervous System Agents / therapeutic use
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / physiopathology*
  • Disease Models, Animal
  • Humans
  • Microglia / drug effects
  • Microglia / physiology
  • Models, Animal
  • Neurons / drug effects
  • Neurons / physiology
  • Neurovascular Coupling / drug effects
  • Neurovascular Coupling / physiology*
  • Zebrafish / physiology*

Substances

  • Central Nervous System Agents