Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer

Andrew J Finch; Esther Baena

doi:10.1158/2159-8290.CD-21-0861

Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer

Cancer Discov. 2021 Sep;11(9):2132-2134. doi: 10.1158/2159-8290.CD-21-0861.

Authors

Andrew J Finch¹, Esther Baena^{2

3}

Affiliations

¹ Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
² Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, United Kingdom. esther.baena@cruk.manchester.ac.uk.
³ Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, United Kingdom.

PMID: 34479975
DOI: 10.1158/2159-8290.CD-21-0861

Abstract

A novel role of NKX3.1 in the mitochondria regulating the transcription of the electron transport chain components is reported. Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation.See related article by Papachristodoulou et al., p. 2316.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Homeodomain Proteins / genetics
Humans
Male
Prostate*
Prostatic Neoplasms*
Reactive Oxygen Species
Transcription Factors / genetics

Substances

Homeodomain Proteins
Reactive Oxygen Species
Transcription Factors