Extended Kalman filter based on stochastic epidemiological model for COVID-19 modelling

Comput Biol Med. 2021 Oct:137:104810. doi: 10.1016/j.compbiomed.2021.104810. Epub 2021 Aug 28.

Abstract

This paper presents a new stochastic-based method for modelling and analysis of COVID-19 spread. A new deterministic Susceptible, Exposed, Infectious, Recovered (Re-infected) and Deceased-based Social Distancing model, named SEIR(R)D-SD, is proposed by introducing the re-infection rate and social distancing factor into the traditional SEIRD (Susceptible, Exposed, Infectious, Recovered and Deceased) model to account for the effects of re-infection and social distancing on COVID-19 spread. The deterministic SEIRD(R)D-SD model is further converted into the stochastic form to account for uncertainties involved in COVID-19 spread. Based on this, an extended Kalman filter (EKF) is developed based on the stochastic SEIR(R)D-SD model to simultaneously estimate both model parameters and transmission state of COVID-19 spread. Simulation results and comparison analyses demonstrate that the proposed method can effectively account for the re-infection and social distancing as well as uncertain effects on COVID-19 spread, leading to improved accuracy for prediction of COVID-19 spread.

Keywords: And extended kalman filter; COVID-19 modelling; Re-infection; Social distancing; Stochastic epidemiological model.

MeSH terms

  • COVID-19*
  • Computer Simulation
  • Disease Susceptibility
  • Humans
  • Physical Distancing
  • SARS-CoV-2