1 Division of Structural Biology, The Institute of Cancer Research, London, SW7 3RP, UK; Fondazione Human Technopole, Structural Biology Research Centre, 20157, Milan, Italy. Electronic address: alessandro.vannini@fht.org.
2 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: ivan.marazzi@mssm.edu.
Valencia-Sánchez et al. (2021) and Liu et al. (2021) provide structural and biological insights about the existence and importance of a nucleosome-like particle in a family of giant viruses.