Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Yun-Chi Wang; Zhi-Hong Wang; Te-Chun Shen; Wen-Shin Chang; Si-Zein Huang; Chien-Chih Yu; Jaw-Chyun Chen; Yu-Chen Hsiau; Jai-Sing Yang; Chia-Wen Tsai; DA-Tian Bau

doi:10.21873/anticanres.15243

Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Anticancer Res. 2021 Sep;41(9):4387-4393. doi: 10.21873/anticanres.15243.

Authors

Yun-Chi Wang^{1

2}, Zhi-Hong Wang³, Te-Chun Shen², Wen-Shin Chang^{1

2}, Si-Zein Huang⁴, Chien-Chih Yu⁵, Jaw-Chyun Chen⁶, Yu-Chen Hsiau², Jai-Sing Yang⁷, Chia-Wen Tsai^{1

2}, DA-Tian Bau^{8

2

9}

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
² Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
³ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
⁴ Institute of New Drug Development, China Medical University, Taichung, Taiwan, R.O.C.
⁵ School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
⁶ Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
⁷ Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁸ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com.
⁹ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

PMID: 34475058
DOI: 10.21873/anticanres.15243

Abstract

Background/aim: Breast cancer incidence is highest among women worldwide, and practical markers for personalized therapeutic strategies are few. Interleukin-12 (IL-12) is a cytokine that is reported to be significantly lower in healthy controls than breast cancer cases, however, its genotypic contribution to carcinogenesis has never been revealed in breast cancer. We examined whether IL-12A rs568408 and rs2243115 genotypes contribute to elevated breast cancer risk and summarized related literature among other cancers.

Materials and methods: IL-12A genotypic profiles were determined among 1,232 breast cancer cases and 1,232 healthy controls via polymerase chain reaction-restriction fragment length polymorphism methodology.

Results: The variant genotypes of IL-12A rs568408 and rs2243115 were not found to be significantly associated with elevated breast cancer risk (both p>0.05).

Conclusion: IL-12A rs568408 and rs2243115 genotypes may not serve as good predictors of breast cancer risk.

Keywords: Breast cancer; Taiwan; genotype; interleukin-12A; polymorphism.

MeSH terms

Adult
Breast Neoplasms / genetics*
Case-Control Studies
Female
Genetic Association Studies / methods*
Genetic Predisposition to Disease
Humans
Interleukin-12 Subunit p35 / genetics*
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide*

Substances

IL12A protein, human
Interleukin-12 Subunit p35