New technologies for improved relevance in miRNA research

Trends Genet. 2021 Dec;37(12):1060-1063. doi: 10.1016/j.tig.2021.08.006. Epub 2021 Aug 30.

Abstract

After a number of years of research in the field of miRNA, the robustness and biological relevance of many published articles is increasingly being questioned. We propose the use of new RNA-seq approaches, genome editing technologies, and updated public databases to improve the quality, reliability, and relevance of published data.

Keywords: CRISPR; RNA sequencing; genome editing; microRNA; noncoding RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CRISPR-Cas Systems
  • Gene Editing
  • MicroRNAs* / genetics
  • Reproducibility of Results

Substances

  • MicroRNAs