Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery

Chem Commun (Camb). 2021 Sep 23;57(76):9728-9731. doi: 10.1039/d1cc04169j.

Abstract

Fluorescently labeled calix[4]arene glycoconjugates demonstrate multifunctional potential in both Warburg effect mediated tumor imaging and GLUT1 targeted drug delivery. Nitrobenzoxadiazole and mannose conjugated NBD-Man-CA was found to be selectively recognized by GLUT1 and act as a "molecular carrier" for selective tumor targeting.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Calixarenes / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Delivery Systems*
  • Drug Screening Assays, Antitumor
  • Glucose Transporter Type 1 / antagonists & inhibitors
  • Glucose Transporter Type 1 / metabolism
  • Humans
  • Luminescence*
  • Mammary Neoplasms, Experimental / diagnostic imaging
  • Mammary Neoplasms, Experimental / drug therapy
  • Mammary Neoplasms, Experimental / pathology
  • Mice
  • Molecular Structure
  • Optical Imaging*
  • Oxadiazoles / chemical synthesis
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology*

Substances

  • Antineoplastic Agents
  • Glucose Transporter Type 1
  • Oxadiazoles
  • SLC2A1 protein, human
  • Calixarenes