Abstract
Fluorescently labeled calix[4]arene glycoconjugates demonstrate multifunctional potential in both Warburg effect mediated tumor imaging and GLUT1 targeted drug delivery. Nitrobenzoxadiazole and mannose conjugated NBD-Man-CA was found to be selectively recognized by GLUT1 and act as a "molecular carrier" for selective tumor targeting.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Calixarenes / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Delivery Systems*
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Drug Screening Assays, Antitumor
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Glucose Transporter Type 1 / antagonists & inhibitors
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Glucose Transporter Type 1 / metabolism
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Humans
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Luminescence*
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Mammary Neoplasms, Experimental / diagnostic imaging
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Mammary Neoplasms, Experimental / drug therapy
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Mammary Neoplasms, Experimental / pathology
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Mice
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Molecular Structure
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Optical Imaging*
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Oxadiazoles / chemical synthesis
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology*
Substances
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Antineoplastic Agents
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Glucose Transporter Type 1
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Oxadiazoles
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SLC2A1 protein, human
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Calixarenes