Measuring the Effects of Berberine on Serum Prooxidant-Antioxidant Balance in Metabolic Syndrome

Tannaz Jamialahmadi; Paul C Guest; Aida Tasbandi; Khalid Al-Rasadi; Amirhossein Sahebkar

doi:10.1007/978-1-0716-1558-4_22

Measuring the Effects of Berberine on Serum Prooxidant-Antioxidant Balance in Metabolic Syndrome

Methods Mol Biol. 2022:2343:309-318. doi: 10.1007/978-1-0716-1558-4_22.

Authors

Tannaz Jamialahmadi^{1

2}, Paul C Guest^{3

4}, Aida Tasbandi⁵, Khalid Al-Rasadi⁶, Amirhossein Sahebkar^{7

8

9}

Affiliations

¹ Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.
² Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
⁴ Charlesworth House, Debden, Essex, UK.
⁵ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Medical Research Centre, Sultan Qaboos University, Muscat, Oman.
⁷ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
⁸ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
⁹ School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.

PMID: 34473333
DOI: 10.1007/978-1-0716-1558-4_22

Abstract

Disturbances in the prooxidant-antioxidant balance can occur in metabolic syndrome. Here, we present a protocol for the setup of a clinical trial of metabolic syndrome patients treated with berberine, a dietary phytochemical of the Berberis vulgaris plant, or placebo. The main aim is to obtain a quick and real-time assessment on the overall redox state based on measurement of the prooxidant-antioxidant balance.

Keywords: Barberry; Metabolic syndrome; Natural products; Prooxidant–antioxidant balance; Reactive oxygen species.

MeSH terms

Antioxidants
Berberine
Berberis
Humans
Metabolic Syndrome* / drug therapy
Reactive Oxygen Species

Substances

Antioxidants
Reactive Oxygen Species
Berberine