Time to Resolution of Infection in COVID-19 Patients: the Experience of a Tertiary Medical Center in Israel

Jpn J Infect Dis. 2022 Mar 24;75(2):144-147. doi: 10.7883/yoken.JJID.2021.215. Epub 2021 Aug 31.

Abstract

With the spread of coronavirus disease, reports have indicated that young patients are usually asymptomatic with a short convalescence period. The current study compared the time to resolution of infection in symptomatic and asymptomatic patients. Seventy-six patients aged 44.4 ± 23.3 years were admitted to the coronavirus disease 2019 (COVID-19) unit during the study period. Data were collected from patient records. Throat and nasal swabs for COVID-19 were collected for reverse transcriptase-polymerase chain reaction (RT-PCR). Time to resolution of infection was defined as the number of days from the date of the first COVID-19 positive outcome to the second consecutive negative PCR results. Most patients showed COVID-19 signs and symptoms (71.1%) between 1 and 6 days, and the rest were asymptomatic. No association was found between the time to resolution of infection and the presence of COVID-19 signs and symptoms (symptomatic: median [Md] 10.0, 95% confidence interval [CI] 8.4-11.6; asymptomatic: Md 15.0, 95% CI 10.5-15.5; P = 0.54). Age was not correlated with the number of COVID-19 signs and symptoms (r = 0.13, P = 0.37) or with the time to resolution of infection (r = 0.06, P = 0.58). In patients with mild to moderate symptoms, the time to resolution of infection from COVID-19 is not different from that in asymptomatic patients.

Keywords: COVID-19; symptomatic vs asymptomatic patients; time to resolution of infection.

MeSH terms

  • Adult
  • Aged
  • COVID-19 Testing
  • COVID-19* / diagnosis
  • Hospitalization
  • Humans
  • Israel / epidemiology
  • Middle Aged
  • SARS-CoV-2
  • Young Adult