Mizaj as an Index in Persian Traditional Medicine Index Could Associate with Sensitivity to the Radiation

Fatemeh Asghari; Kourosh Ebrahimnejad Gorji; Seyyed Ali Mozaffarpur; Ali Shabestani Monfared; Ebrahim Zabihi; Zeinab Abedian; Hoda Shirafkan; Fatemeh Niksirat; Sajad Borzoueisileh

doi:10.31661/gmj.v9i0.1705

Mizaj as an Index in Persian Traditional Medicine Index Could Associate with Sensitivity to the Radiation

Galen Med J. 2020 Aug 19:9:e1705. doi: 10.31661/gmj.v9i0.1705. eCollection 2020.

Authors

Fatemeh Asghari¹, Kourosh Ebrahimnejad Gorji², Seyyed Ali Mozaffarpur³, Ali Shabestani Monfared⁴, Ebrahim Zabihi⁵, Zeinab Abedian⁵, Hoda Shirafkan⁶, Fatemeh Niksirat², Sajad Borzoueisileh^{1

5}

Affiliations

¹ Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
² Department of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
³ Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁴ Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁵ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁶ Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Abstract

Background: The sensitivity to the radiation among human population depends on various parameters. This variation could lead to dissimilar outcome of radiotherapy in similar situations. Mizaj is a well-known term in Persian medicine that present an individualized medicine viewpoint. All of the people will be categorized in cold, moderate, and warm Mizaj. In this study, we aimed to evaluate the possible association between Mizaj and radiosensitivity by comet assay.

Materials and methods: Peripheral blood sample of 30 healthy volunteers (10 cold, 11 moderate and nine warm Mizaj) were taken and divided into two identical parts. The first part was exposed to 4 Gy x-rays, and the second part was regarded as the sham control. Then, DNA damages of samples were evaluated by the neutral comet assay.

Results: The results showed that the mean percentage of damaged cells, in all of the irradiated groups including A (warm), B (moderate) and C (cold) was significantly higher than the controls (P<0.001). Moreover, DNA damage rate in the irradiated warm Mizaj group was higher than both cold and moderate irradiated groups, but the difference between moderate and cold irradiated groups was not statistically significant.

Conclusion: The results are indicating that warm Mizaj persons could be more radiosensitive than other groups, which their importance in radiotherapy individualization should be evaluated in more extensive studies.

Keywords: Comet Assay; Complementary Therapies; Mizaj; Radiation Tolerance; Traditional.