Illuminating the Fc dependence of SARS-CoV-2 neutralization

Joseph C González; Taia T Wang

doi:10.1016/j.immuni.2021.08.024

Illuminating the Fc dependence of SARS-CoV-2 neutralization

Immunity. 2021 Sep 14;54(9):1912-1914. doi: 10.1016/j.immuni.2021.08.024. Epub 2021 Aug 25.

Authors

Joseph C González¹, Taia T Wang²

Affiliations

¹ Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Immunology Interdepartmental Program, Stanford University, Stanford, CA, USA.
² Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: taiawang@stanford.edu.

Abstract

Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Antibodies, Neutralizing*
Antibodies, Viral
COVID-19*
Humans
Mice
SARS-CoV-2
Spike Glycoprotein, Coronavirus

Substances

Antibodies, Neutralizing
Antibodies, Viral
Spike Glycoprotein, Coronavirus

Abstract

Publication types

MeSH terms

Substances

Grants and funding