Spinal cord injury (SCI) is a complex pathological process. Based on the encouraging results of preclinical experiments, some stem cell therapies have been translated into clinical practice. Mesenchymal stem cells (MSCs) have become one of the most important seed cells in the treatment of SCI due to their abundant sources, strong proliferation ability and low immunogenicity. However, the survival rate of MSCs transplanted to spinal cord injury is rather low, which hinders its further clinical application. In recent years, hydrogel materials have been widely used in tissue engineering because of their good biocompatibility and biodegradability. The treatment strategy of hydrogel combined with MSCs has made some progress in SCI repair. This review discusses the significance and the existing problems of MSCs in the repair of SCI. It also describes the research progress of hydrogel combined with MSCs in repairing SCI, and prospects its application in clinical research, aiming at providing reference and new ideas for future SCI treatment.
脊髓损伤是一个复杂的病理过程。基于临床前实验令人鼓舞的结果，部分干细胞治疗已转化为临床实践。间充质干细胞因其来源丰富、增殖能力强、低免疫原性，现已成为干细胞移植治疗脊髓损伤策略中重要的种子细胞之一。然而，将间充质干细胞移植到脊髓损伤处后的存活率较低，阻碍了其在临床上的进一步应用。近年来，水凝胶材料因其良好的生物相容性、生物降解性被广泛应用于组织工程，水凝胶联合间充质干细胞的治疗策略在脊髓损伤修复中已取得一定进展。本综述讨论了间充质干细胞修复脊髓损伤的意义以及目前存在的问题，阐述了水凝胶联合间充质干细胞修复脊髓损伤的研究进展并对其在临床研究中的应用进行了展望，旨在为该技术今后在脊髓损伤治疗中的应用提供借鉴和新思路。.
Keywords: adipose derived stem cells; hydrogel; mesenchymal stem cells; spinal cord injury.