SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hypertension at Medium to Very High Risk

Stephane Laurent; Gilles Chatellier; Michel Azizi; David Calvet; Gabriel Choukroun; Nicolas Danchin; Pascal Delsart; Xavier Girerd; Philippe Gosse; Hakim Khettab; Gerard London; Jean-Jacques Mourad; Bruno Pannier; Helena Pereira; Dominique Stephan; Paul Valensi; Pedro Cunha; Krzysztof Narkiewicz; Rosa-Maria Bruno; Pierre Boutouyrie; SPARTE Investigators

doi:10.1161/HYPERTENSIONAHA.121.17579

SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hypertension at Medium to Very High Risk

Hypertension. 2021 Sep;78(4):983-995. doi: 10.1161/HYPERTENSIONAHA.121.17579. Epub 2021 Aug 30.

Authors

Stephane Laurent^{1

2}, Gilles Chatellier^{1

2

3}, Michel Azizi^{1

2

4

5}, David Calvet^{6

7}, Gabriel Choukroun^{8

9}, Nicolas Danchin^{1

2

10}, Pascal Delsart¹¹, Xavier Girerd¹², Philippe Gosse¹³, Hakim Khettab^{2

14}, Gerard London¹⁵, Jean-Jacques Mourad¹⁶, Bruno Pannier¹⁷, Helena Pereira³, Dominique Stephan^{18

19}, Paul Valensi²⁰, Pedro Cunha^{21

22}, Krzysztof Narkiewicz²³, Rosa-Maria Bruno^{1

2

14}, Pierre Boutouyrie^{1

2

14}; SPARTE Investigators

Affiliations

¹ From the Université de Paris, France (S.L., G. Chatellier, M.A., N.D., R.-M.B., P.B.).
² Assistance-Publique Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France (S.L., G. Chatellier, M.A., N.D., H.K., R.-M.B., P.B.).
³ Clinical Research Unit, INSERM U970, Paris (G. Chatellier, H.P.).
⁴ Hypertension Department and DMU CARTE, Paris, France (M.A.).
⁵ INSERM, CIC1418, Paris, France (M.A.).
⁶ Neurology department, GHU Paris Psychiatrie Neurosciences, Sainte-Anne Hospital (D.C.).
⁷ INSERM UMR 1266, FHU NeuroVasc, Paris, France (D.C.).
⁸ Nephrology Dialysis Transplantation Department, CHU Amiens, France (G. Choukroun).
⁹ MP3CV Research Unit, University Picardie Jules Verne, France (G. Choukroun).
¹⁰ Cardiology Department, Georges Pompidou Hospital, Paris, France (N.D.).
¹¹ CHU Lille, Institut Cœur Poumon, Lille, France (P.D.).
¹² ICAN, Sorbonne University, Assistance-Publique Hopitaux de Paris, Paris, France (X.G.).
¹³ Cardiology Department, Saint Andre Hospital, CHU Bordeaux, France (P.G.).
¹⁴ INSERM U970, Cardiovascular Research Center - PARCC, Paris, France (H.K., R.-M.B., P.B.).
¹⁵ Department of Nephrology, Manhes Hospital, Fleury Merogis, France(G.L.).
¹⁶ Paris Saint-Joseph Hospital, Paris, France (J.-J.M.).
¹⁷ Department of Internal Medicine, Manhes Hospital, Fleury Merogis, France (B.P.).
¹⁸ University of Strasbourg, France (D.S.).
¹⁹ UMR 1260, INSERM-University of Strasbourg, France (D.S.).
²⁰ Unit of Endocrinology-Diabetology-Nutrition, Assistance-Publique Hopitaux de Paris, Jean Verdier Hospital, University Sorbonne Paris Cite, Bondy, France (P.V.).
²¹ Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department, Guimaraes, Portugal (P.C.).
²² Life and Health Research Institute (ICVS/3B's), Minho University, Portugal (P.C.).
²³ Department of Hypertension and Diabetology, Faculty of Medicine, Medical University of Gdansk, Debinki, Gdansk, Poland (K.N.).

Abstract

[Figure: see text].

Keywords: blood pressure; clinical trial; hypertension; renin-angiotensin system; surrogate end point; vascular stiffness.

Publication types

Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Blood Pressure
Cardiovascular Diseases / prevention & control*
Female
Humans
Hypertension / complications
Hypertension / drug therapy*
Hypertension / physiopathology
Male
Middle Aged
Prospective Studies
Pulse Wave Analysis
Vascular Stiffness / drug effects*
Vascular Stiffness / physiology