Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24 Months of Follow-Up: Results from US Dermatology Electronic Medical Records

April W Armstrong; Dhaval Patil; Eugenia Levi; Catherine B McGuiness; Xin Wang; Yi Wang; Chi-Chang Chen; Elizabeth Nguyen; Paul S Yamauchi

doi:10.1007/s13555-021-00599-5

Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24 Months of Follow-Up: Results from US Dermatology Electronic Medical Records

Dermatol Ther (Heidelb). 2021 Oct;11(5):1733-1749. doi: 10.1007/s13555-021-00599-5. Epub 2021 Aug 28.

Authors

April W Armstrong¹, Dhaval Patil², Eugenia Levi², Catherine B McGuiness³, Xin Wang³, Yi Wang³, Chi-Chang Chen³, Elizabeth Nguyen², Paul S Yamauchi⁴

Affiliations

¹ Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
² Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
³ IQVIA, Plymouth Meeting, PA, USA.
⁴ David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. paulyamauchi@yahoo.com.

Abstract

Introduction: Information on the long-term treatment satisfaction with secukinumab for patients with plaque psoriasis in real-world settings is limited. The objective of this study was to describe real-world treatment satisfaction in patients with plaque psoriasis who initiated secukinumab using data from an electronic medical records-based dermatology database.

Methods: Patients aged ≥ 18 years with plaque psoriasis in Modernizing Medicine Data Services' affiliate's database who received secukinumab 3/1/2018-1/21/2020 were included. Satisfaction with the treatment's effectiveness in clearing the skin of psoriasis was evaluated using a 5-point Likert scale during the 12-month baseline period and at 6-, 12-, 18-, and 24-month postindex visits for the overall population and at 6-, 12-, and 18-month postindex visits for subgroups stratified by prior biologic and systemic therapy use. Additionally, satisfaction levels were assessed among patients who were unsatisfied with treatment at baseline.

Results: Overall, 82.3% agreed that secukinumab was effective in clearing their skin at 6 months, which was maintained through 12 (81.7%), 18 (83.3%), and 24 months (81.4%). Similar results were observed in biologic-experienced/naive and systemic-experienced/naive patients. Overall mean (SD) treatment satisfaction improved from 2.49 (1.36) at baseline to 1.77 (1.06) at 6 months, with similar improvements in satisfaction scores reported at each follow-up period up through 24 months. Of the patients who were not satisfied at baseline, 77.9% reported being satisfied with their treatment at 6 months, which continued through 12 (74.4%), 18 (82.8%), and 24 months (71.4%). Patients receiving secukinumab experienced meaningful changes in percent affected body surface area and Physician Global Assessment scores that were sustained through 24 months, regardless of prior treatment experience.

Conclusions: These real-world findings highlight the high level of sustained satisfaction with secukinumab treatment for improving and maintaining skin clearance in patients with moderate-to-severe disease, regardless of prior treatment experience.

Keywords: Dermatology electronic medical records; Plaque psoriasis; Secukinumab; Treatment satisfaction.