Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models

Adv Pharmacol. 2021:92:151-190. doi: 10.1016/bs.apha.2021.03.008. Epub 2021 May 3.

Abstract

This chapter covers the known effects of endocrine disrupting chemicals (EDCs) on reproductive disorders. The EDCs represented are highly studied, including plasticizers (bisphenols and phthalates), chemicals in personal care products (parabens), persistent environmental contaminants (polychlorinated biphenyls), and chemicals in pesticides or herbicides. Both female and male reproductive disorders are reviewed in the chapter. Female disorders include infertility/subfertility, irregular reproductive cycles, early menopause, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and uterine fibroids. Male disorders include infertility/subfertility, cryptorchidism, and hypospadias. Findings from both human and animal studies are represented.

Keywords: Bisphenol; Endocrine disrupting chemical; Fertility; Paraben; Perfluorochemical; Pesticides; Phthalate; Polychlorinated biphenyls; Reproduction; Reproductive system health.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endocrine Disruptors* / toxicity
  • Environmental Exposure
  • Environmental Pollutants*
  • Female
  • Humans
  • Male
  • Models, Animal

Substances

  • Endocrine Disruptors
  • Environmental Pollutants