8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

Milena Ignatova; Nevena Manolova; Iliya Rashkov; Nadya Markova; Rositsa Kukeva; Radostina Stoyanova; Ani Georgieva; Reneta Toshkova

doi:10.3390/polym13162690

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu²⁺ and Fe³⁺ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

Polymers (Basel). 2021 Aug 12;13(16):2690. doi: 10.3390/polym13162690.

Authors

Milena Ignatova¹, Nevena Manolova¹, Iliya Rashkov¹, Nadya Markova², Rositsa Kukeva³, Radostina Stoyanova³, Ani Georgieva⁴, Reneta Toshkova⁴

Affiliations

¹ Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St. Bl. 103A, BG-1113 Sofia, Bulgaria.
² Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 26, BG-1113 Sofia, Bulgaria.
³ Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St. Bl. 11, BG-1113 Sofia, Bulgaria.
⁴ Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev St. Bl. 25, BG-1113 Sofia, Bulgaria.

Abstract

Novel poly(vinyl alcohol) (PVA)/chitosan (Ch)-based fibrous materials containing an ionizable model drug, 8-hydroxyquinoline-5-sulfonic acid (SQ), were successfully fabricated by electrospinning. Complexes between the components of the crosslinked PVA/Ch/SQ mats and Cu²⁺ and Fe³⁺ ions were formed. The coordination of these ions in the mats was examined by electron paramagnetic resonance spectroscopy (EPR). The microbiological screening against S. aureus and C. albicans revealed that both the incorporation of SQ in the mats and the complexation with Cu²⁺ and Fe³⁺ imparted to these materials antibacterial and antifungal activities. Moreover, the SQ-containing mats and their complexes displayed good cytotoxicity against human cervical HeLa tumor cells. The most prominent was the cytotoxicity of the Cu²⁺ complex of the mats. The combined antibacterial, antifungal and in vitro antitumor activities render these novel materials promising candidates for wound dressing applications and for application in the local treatment of cervical tumors.

Keywords: 8-hydroxyquinoline-5-sulfonic acid; antibacterial activity; antifungal activity; antitumor efficacy; chitosan; electrospinning; poly(vinyl alcohol).

Grants and funding

KP-06-N39/13/2019/Bulgarian National Science Fund