Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations

Abstract

Garlic (Allium sativum L.) is one of the oldest plants cultivated for its dietary and medicinal values. This incredible plant is endowed with various pharmacological attributes, such as antimicrobial, antiarthritic, antithrombotic, antitumor, hypoglycemic, and hypolipidemic activities. Among the various beneficial pharmacological effects of garlic, the anticancer activity is presumably the most studied. The consumption of garlic provides strong protection against cancer risk. Taking into account the multi-targeted actions and absence of considerable toxicity, a few active metabolites of garlic are probably to play crucial roles in the killing of cancerous cells. Garlic contains several bioactive molecules with anticancer actions and these include diallyl trisulfide, allicin, diallyl disulfide, diallyl sulfide, and allyl mercaptan. The effects of various garlic-derived products, their phytoconstituents and nanoformulations have been evaluated against skin, prostate, ovarian, breast, gastric, colorectal, oral, liver, and pancreatic cancers. Garlic extract, its phytocompounds and their nanoformulations have been shown to inhibit the different stages of cancer, including initiation, promotion, and progression. Besides, these bioactive metabolites alter the peroxidation of lipid, activity of nitric oxide synthetase, nuclear factor-κB, epidermal growth factor receptor, and protein kinase C, cell cycle, and survival signaling. The current comprehensive review portrays the functions of garlic, its bioactive constituents and nanoformulations against several types of cancers and explores the possibility of developing these agents as anticancer pharmaceuticals.

Keywords: Ajoene (PubChem CID: 5386591); Allicin; Allicin (PubChem CID: 65036); Alliin (PubChem CID: 87310); Allium sativum; Allyl methyl sulfide (PubChem CID: 66282); Antineoplastic agents; Cancer; Diallyl disulfide; Diallyl disulfide (PubChem CID: 16590); Diallyl sulfide (PubChem CID: 11617); Diallyl trisulfide (PubChem CID: 16315); Garlic; Molecular mechanisms; N-trans-feruloyloctopamine (PubChem CID: 24096391); Nano-formulations; Thiacremonone (PubChem CID: 539170); γ-glutamyl-S-allyl-L-cysteine (PubChem CID: 11346811).